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Antitumor Therapeutics: A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics (Adv. Funct. Mater. 51/2019)
Author(s) -
Wannasarit Saowanee,
Wang Shiqi,
Figueiredo Patrícia,
Trujillo Claudia,
Eburnea Francesca,
SimónGracia Lorena,
Correia Alexandra,
Ding Yaping,
Teesalu Tambet,
Liu Dongfei,
Wiwattanapatapee Ruedeekorn,
Santos Hélder A.,
Li Wei
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201970351
Subject(s) - oncolytic virus , drug delivery , intracellular , dextran , materials science , nanoparticle , in vitro , nanotechnology , biophysics , virus , virology , biochemistry , chemistry , medicine , biology
In article number 1905352, Shiqi Wang, Hélder A. Santos, Wei Li, and co‐workers report a virus‐mimicking polymeric nanoparticle with endosomolytic activity and pH‐responsive drug release properties. With great drug encapsulation efficiency, in vitro therapeutic efficacy, and oncolytic activity towards 3D tumor spheroids after conjugating tumor penetrating peptides, this nanoparticle shows promising potential for the intracellular delivery of antitumor therapeutics.