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Nanotopography: Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation (Adv. Funct. Mater. 14/2019)
Author(s) -
Visalakshan Rahul M.,
Cavallaro Alex A.,
MacGregor Melanie N.,
Lawrence Emma P.,
Koynov Kaloian,
Hayball John D.,
Vasilev Krasimir
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201970088
Subject(s) - nanotopography , materials science , nanoscopic scale , fibrinogen , nanotechnology , biophysics , chemistry , biology , biochemistry
In article number 1807453 , Krasimir Vasilev and co‐workers describe the role of surface nanotopography in modulating immune responses. By using model surfaces purposely engineered at the nanoscale, the team demonstrates nanotopography scale dependent fibrinogen unfolding, which leads to the exposure of normally hidden peptide sequences causing activation of the Mac‐1 receptor of inflammatory cells.