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Drug Delivery: Activated Platelets‐Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer (Adv. Funct. Mater. 13/2019)
Author(s) -
Zhang Yujie,
Zhu Xi,
Chen Xinli,
Chen Qinjun,
Zhou Wenxi,
Guo Qin,
Lu Yifei,
Li Chao,
Zhang Yu,
Liang Donghui,
Sun Tao,
Wei Xunbin,
Jiang Chen
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201970086
Subject(s) - metastatic breast cancer , platelet , micelle , metastasis , drug delivery , targeted drug delivery , cancer research , drug , triple negative breast cancer , circulating tumor cell , materials science , cancer , breast cancer , pharmacology , medicine , nanotechnology , chemistry , aqueous solution
In article number 1806620 , Chen Jiang and co‐workers, inspired by the ability of activated platelets to track tumor metastasis, develop a novel activated plateletstargeting micelle for efficient anticancer drug delivery to primary and metastatic tumors. After specifically binding to activated platelets in circulation, the micelles capture circulating tumor cells (CTCs) through the “platelet bridge” and eliminate CTCs to prevent metastasis.