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Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy
Author(s) -
Gao Ge,
Jiang YaoWen,
Guo Yuxin,
Jia HaoRan,
Cheng Xiaotong,
Deng Yu,
Yu XinWang,
Zhu YaXuan,
Guo HaoYue,
Sun Wei,
Liu Xiaoyang,
Zhao Jing,
Yang Shihe,
Yu ZhiWu,
Raya Fatima Maria Sierra,
Liang Gaolin,
Wu FuGen
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201909391
Subject(s) - photothermal therapy , in vivo , glucose oxidase , cancer research , pharmacology , biophysics , heat shock protein , materials science , enzyme , chemistry , biochemistry , nanotechnology , medicine , biology , microbiology and biotechnology , gene
Abstract Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild‐temperature PTT might lead to toxic side effects. Glucose oxidase (GOx) consumes glucose, leading to adenosine triphosphate supply restriction and consequent HSP inhibition. Therefore, a combinational use of an HSP inhibitor and GOx not only enhances mild‐temperature PTT but also minimizes the toxicity of the inhibitor. However, a GOx and HSP inhibitor‐encapsulating nanostructure, designed for enhancing its mild‐temperature tumor PTT efficiency, has not been reported. Thermosensitive GOx/indocyanine green/gambogic acid (GA) liposomes (GOIGLs) are reported to enhance the efficiency of mild‐temperature PTT of tumors via synergistic inhibition of tumor HSP by the released GA and GOx, together with another enzyme‐enhanced phototherapy effect. In vitro and in vivo results indicate that this strategy of tumor starvation and phototherapy significantly enhances mild‐temperature tumor PTT efficiency. This strategy could inspire people to design more delicate platforms combining mild‐temperature PTT with other therapeutic methods for more efficient cancer treatment.