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Z‐Scheme Heterojunction Functionalized Pyrite Nanosheets for Modulating Tumor Microenvironment and Strengthening Photo/Chemodynamic Therapeutic Effects
Author(s) -
Pan Chao,
Ou Meitong,
Cheng Qinzhen,
Zhou Yun,
Yu Yongkang,
Li Zimu,
Zhang Fan,
Xia Dehua,
Mei Lin,
Ji Xiaoyuan
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201906466
Subject(s) - materials science , heterojunction , photothermal therapy , redox , photocatalysis , nanotechnology , optoelectronics , photochemistry , chemistry , metallurgy , biochemistry , catalysis
A Z‐scheme heterojunction with high electron–hole pairs separation efficacy and enhanced redox potentials exhibits tremendous potential in photonic theranostics, but still remains unexplored and challenging. Herein, novel 2D thermally oxidized pyrite nanosheets (TOPY NSs) with FeS 2 core and Fe 2 O 3 shell are fabricated combining ball grinding and two‐step probe sonication assisted liquid exfoliation under different solution and air environments. The Fe 2 O 3 shell and Fe 3+ /Fe 2+ inside TOPY NSs can both damage the tumor microenvironment through glutathione consumption and O 2 production, and produce ·OH by Fenton reaction. More interestingly, a direct Z‐scheme heterojunction based on FeS 2 core and Fe 2 O 3 shell is constructed, in which the electrons in the conduction band (CB) of Fe 2 O 3 are recombined with the holes in the valence band (VB) of FeS 2 , leaving stronger reduction/oxidation potentials in the CB of FeS 2 and the VB of Fe 2 O 3 . Under irradiation of a 650 nm laser, the generation of ·O 2 − from O 2 and ·OH from OH − on the CB of FeS 2 and VB of Fe 2 O 3 , respectively, is largely enhanced. Furthermore, the NSs can be triggered by an 808 nm laser to generate local hyperthermia for photothermal therapy. Moreover, the fluorescent, photoacoustic, and photothermal imaging capabilities of the NSs allow multimodal imaging‐guided cancer treatment.