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Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering
Author(s) -
Zhang Yanbo,
Liu Xiaochen,
Zeng Liangdan,
Zhang Jin,
Zuo Jianlin,
Zou Jun,
Ding Jianxun,
Chen Xuesi
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201903279
Subject(s) - materials science , cartilage , tissue engineering , biomedical engineering , polymer , regeneration (biology) , composite material , anatomy , medicine , biology , microbiology and biotechnology
Abstract Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific‐surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well‐designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering.