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Jellyfish‐Based Smart Wound Dressing Devices Containing In Situ Synthesized Antibacterial Nanoparticles
Author(s) -
Nudelman Roman,
Alhmoud Hashim,
Delalat Bahman,
Fleicher Sharon,
Fine Eran,
Guliakhmedova Tammila,
Elnathan Roey,
Nyska Abraham,
Voelcker Nicolas H.,
Gozin Michael,
Richter Shachar
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201902783
Subject(s) - materials science , electrospinning , scaffold , biocompatibility , nanofiber , nanotechnology , tissue engineering , nanoparticle , wound healing , wound dressing , in situ , biomedical engineering , composite material , polymer , chemistry , biology , organic chemistry , medicine , immunology , metallurgy
Although the negative consequences of the global phenomenon of jellyfish (JF) swarms are well recognized, the use of their biomass for practical applications is mostly limited to a niche in the Asian food industry. This fact is quite surprising since JF's biomass comprises useful biomaterials such as Q‐mucin glycoprotein and collagen. In this work, the JF biomass, collected from two different species, is used to prepare electrospun scaffolds composed of nanometric “core–shell”‐type fibers, in which adjustment of the electrospinning process parameters can easily control their mechanical, morphological, and chemical properties. This nonwoven scaffold shows excellent biocompatibility and biodegradability, indicating suitability for biomedical research contexts. Performed cell proliferation assays show that the scaffold could support the growth of cardiac cells, fitting the requirement of tissue engineering. Additional incorporation of in situ‐generated silver nanoparticles in these nanofibers produced mats with potent antibacterial properties. Preclinical trials with the resulted mats on porcine wound healing models exhibit fast and complete healing of wounds.