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Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe 2 O 4 @Metal–Organic Frameworks for Enhanced Photodynamic Therapy
Author(s) -
Yin ShengYan,
Song Guosheng,
Yang Yue,
Zhao Yan,
Wang Peng,
Zhu LongMin,
Yin Xia,
Zhang XiaoBing
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201901417
Subject(s) - photodynamic therapy , metal organic framework , tumor microenvironment , reactive oxygen species , materials science , tumor hypoxia , porphyrin , glutathione , in vivo , catalysis , photosensitizer , cancer research , biophysics , radiation therapy , photochemistry , chemistry , biochemistry , enzyme , organic chemistry , medicine , tumor cells , microbiology and biotechnology , adsorption , biology
Abstract Reactive oxygen species (ROS)‐based cancer therapy, such as photodynamic therapy (PDT), is subject to the hypoxia and overexpressed glutathione (GSH) found in the tumor microenvironment (TME). Herein, a novel strategy is reported to continuously and simultaneously regulate tumor hypoxia and reducibility in order to achieve the desired therapeutic effect. To accomplish this, a biocompatible nanoplatform (MnFe 2 O 4 @metal–organic framework (MOF)) is developed by integrating a coating of porphyrin‐based MOF as the photosensitizer and manganese ferrite nanoparticle (MnFe 2 O 4 ) as the nanoenzyme. The synthetic MnFe 2 O 4 @MOF nanoplatform exhibits both catalase‐like and glutathione peroxidase‐like activities. Once internalized in the tumor, the nanoplatform can continuously catalyze H 2 O 2 to produce O 2 to overcome the tumor hypoxia by cyclic Fenton reaction. Meanwhile, combined with the Fenton reaction, MnFe 2 O 4 @MOF is able to persistently consume GSH in the presence of H 2 O 2 , which decreases the depletion of ROS upon laser irradiation during PDT and achieves better therapeutic efficacy in vitro and in vivo. Moreover, the nanoplatform integrates a treatment modality with magnetic resonance imaging, along with persistent regulation of TME, to promote more precise and effective treatment for future clinical application.