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Zirconyl Hydrogenphosphate Nanocontainers for Flexible Transport and Release of Lipophilic Cytostatics, Insecticides, and Antibiotics
Author(s) -
Rein Viktor,
Meschkov Anna,
Hagens Kristine,
Redinger Natalja,
Schepers Ute,
Mehlhorn Heinz,
Schaible Ulrich E.,
Feldmann Claus
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201900543
Subject(s) - nanocarriers , materials science , combinatorial chemistry , aqueous solution , cytotoxicity , drug delivery , nanotechnology , chemistry , organic chemistry , in vitro , biochemistry
Administration of lipophilic drugs is often restricted by poor aqueous solubility (especially in blood), limited membrane permeability, uncontrolled drug leakage, and aggregation of lipophilic drugs. As a new nanocarrier concept, LC@ZrO(mdp)@ZrO(HPO 4 ) core@shell nanocontainers (LC: lipophilic cavity; mdp: monododecylphosphate) are presented. As a proof of concept, the nanocontainers are used to encapsulate different types of lipophilic molecules such as the fluorescent dye lumogen red (LR), the cytostatic drug irinotecan (ITC), the insecticide cypermethrin (CM), and the tuberculosis antibiotic benzothiazinone‐043 (BTZ). Synthesis strategy and material structure of the nanocontainers are discussed in detail. LR@ZrO(mdp)@ZrO(HPO 4 ), as the first example, shows intense red emission and successful incorporation of LR into the nanocontainers. As ex vivo application, CM@ZrO(mdp)@ZrO(HPO 4 ) nanocontainers can be used to repel and even kill mosquitoes or flies being in contact with the insecticide‐loaded nanocontainers. The drugs ITC and BTZ—after encapsulation in ITC@ZrO(mdp)@ZrO(HPO 4 ) and BTZ@ZrO(mdp)@ZrO(HPO 4 ) nanocontainers—show high activity at low cytotoxicity in in vitro studies against tumor cells (HeLa, SK‐Mel‐28, HTC116, A549, RAW264.7) and tuberculosis ( Mycobacterium tuberculosis ‐infected macrophages). Taken together, the different lipophilic molecules (LR, CM, ITC, BTZ) point to the adaptability and performance of the novel zirconyl hydrogenphosphate nanocontainer concept.