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Drug Delivery: pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease (Adv. Funct. Mater. 50/2018)
Author(s) -
Bertoni Serena,
Liu Zehua,
Correia Alexandra,
Martins João Pedro,
Rahikkala Antti,
Fontana Flavia,
Kemell Marianna,
Liu Dongfei,
Albertini Beatrice,
Passerini Nadia,
Li Wei,
Santos Hélder A.
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870353
Subject(s) - inflammatory bowel disease , materials science , drug , drug delivery , composite number , pharmacology , absorption (acoustics) , targeted drug delivery , reactive oxygen species , permeation , medicine , nanotechnology , disease , composite material , chemistry , membrane , biochemistry
In article number 1806175 , Nadia Passerini, Wei Li, Hélder A. Santos, and co‐workers report a nano‐in‐micro composite for targeted therapy of inflammatory bowel disease via oral administration. The composite responds sequentially to pH and reactive oxygen species. The drug permeation through intestinal epithelium is also limited, providing a promising approach to limit unspecific absorption and systemic side effects.