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Drug Screening: Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver‐Specific Microenvironment as a Drug Testing Platform (Adv. Funct. Mater. 37/2018)
Author(s) -
Jin Yoonhee,
Kim Jin,
Lee Jung Seung,
Min Sungjin,
Kim Suran,
Ahn DaHee,
Kim YunGon,
Cho SeungWoo
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870266
Subject(s) - organoid , drug , microfluidics , drug delivery , liver tissue , drug discovery , materials science , biomedical engineering , nanotechnology , cancer research , pharmacology , microbiology and biotechnology , medicine , bioinformatics , biology
High‐throughput drug screening and drug testing requires artificial liver mimics to account for metabolization. In article number 1801954 , Seung‐Woo Cho and co‐workers report a drug testing platform based on vascularized, three‐dimensional liver organoids. Resulting from the joint application of direct programming, matrix engineering to represent a liver microenvironment, and microfluidics, the approach is promising as patient‐relevant screening platform for drug development and for cell replacement therapy.