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Cancer Therapy: Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model (Adv. Funct. Mater. 28/2018)
Author(s) -
Liu HaiJun,
Luan Xin,
Feng HaiYi,
Dong Xiao,
Yang SiCong,
Chen ZhongJian,
Cai QinYi,
Lu Qin,
Zhang Yunpeng,
Sun Peng,
Zhao Mei,
Chen HongZhuan,
Lovell Jonathan F.,
Fang Chao
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870196
Subject(s) - polyethylenimine , materials science , delivery system , nanotechnology , mesoporous silica , cancer research , microvesicles , cancer , colorectal cancer , nanoparticle , doxorubicin , microrna , nanomedicine , chemotherapy , biomedical engineering , mesoporous material , medicine , cell culture , biology , biochemistry , transfection , genetics , gene , catalysis
In article number 1801118 Mei Zhao, Chao Fang, and co‐workers develop a smart mesoporous silica nanoparticles (MSN) based nanosystem for doxorubicin and microRNA‐145 co‐delivery (Dm@TMSN). By “weaving” polyethylenimine on the MSN surface through disulfide bonds the counter‐productive dilemma generated from intracellular compartment‐dependent delivery and release of both cargos is overcome. By integrating a peptide‐mediated active targeting strategy, Dm@TMSN exhibits an excellent antitumor effect in an orthotopic colorectal cancer model.