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Biomedical Applications: Engineering of Mature Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Using Substrates with Multiscale Topography (Adv. Funct. Mater. 19/2018)
Author(s) -
Abadi Parisa P. S. S.,
Garbern Jessica C.,
Behzadi Shahed,
Hill Michael J.,
Tresback Jason S.,
Heydari Tiam,
Ejtehadi Mohammad Reza,
Ahmed Nafis,
Copley Elizabeth,
Aghaverdi Haniyeh,
Lee Richard T.,
Farokhzad Omid C.,
Mahmoudi Morteza
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870128
Subject(s) - induced pluripotent stem cell , materials science , tissue engineering , nanotechnology , stem cell , microbiology and biotechnology , neuroscience , biology , biomedical engineering , embryonic stem cell , engineering , biochemistry , gene
Immaturity of cardiomyocytes derived from induced pluripotent stem cells is an important issue in the field of cell therapeutics. In article number 1707378 , Morteza Mahmoudi and co‐workers develop substrates with multi‐scale topography resembling the three‐dimensional features of the native heart environment to address the issue of immaturity of cardiomyocytes. The results show faster differentiation, enhanced maturity, and improved beating.