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Directed Differentiation: MRI‐Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke (Adv. Funct. Mater. 14/2018)
Author(s) -
Lu Liejing,
Wang Yong,
Zhang Fang,
Chen Meiwei,
Lin Bingling,
Duan Xiaohui,
Cao Minghui,
Zheng Chushan,
Mao Jiaji,
Shuai Xintao,
Shen Jun
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870092
Subject(s) - nanomedicine , neural stem cell , gene silencing , materials science , stem cell , nanotechnology , small interfering rna , nanoparticle , microbiology and biotechnology , rna , biology , gene , biochemistry
A multifunctional nanoscale polymersome is developed for directing neuronal differentiation of neural stem cells (NSCs) by Jun Shen and co‐workers in article number 1706769 . Superparamagnetic iron oxide nanoparticles and small interfering RNA can be co‐delivered into NSCs, allowing for directing neuronal differentiation through silencing the NgR gene and non‐invasive migration monitoring. The study shows the great potential of nanomedicine in stroke treatment using stem cell transplantation.