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Nanomedicine: Organic–Inorganic Hybrid Hollow Nanoparticles Suppress Oxidative Stress and Repair Damaged Tissues for Treatment of Hepatic Fibrosis (Adv. Funct. Mater. 13/2018)
Author(s) -
Hayashi Koichiro,
Maruhashi Takuma,
Sakamoto Wataru,
Yogo Toshinobu
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870086
Subject(s) - silibinin , materials science , nanomedicine , oxidative stress , nanoparticle , reactive oxygen species , glutathione , nanotechnology , biophysics , cancer research , biochemistry , medicine , chemistry , biology , enzyme
In article number 1706332 , Koichiro Hayashi and co‐workers describe a nanoparticle‐based treatment as an alternative to transplantation. Multifunctional organic‐inorganic hybrid hollow nanoparticles (HNPs) containing silibinin, which is the most active constituent of silymarin and a long‐used remedy for liver diseases, are synthesized. Glutathione‐induced deformation of the HNPs releases silibinin selectively within hepatic cells. Furthermore, the HNPs suppress reactive oxygen species in the liver.