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Cancer Therapy: DNA‐Au Nanomachine Equipped with i‐Motif and G‐Quadruplex for Triple Combinatorial Anti‐Tumor Therapy (Adv. Funct. Mater. 5/2018)
Author(s) -
Park Hyeongmok,
Kim Jinhwan,
Jung Sungjin,
Kim Won Jong
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201870028
Subject(s) - guanine , photothermal therapy , dna , g quadruplex , materials science , cancer therapy , cytosine , nanotechnology , dna origami , conjugated system , biophysics , combinatorial chemistry , cancer research , chemistry , biochemistry , medicine , nucleotide , polymer , biology , cancer , gene , genetics , nanostructure , composite material
In article 1705416 , Won Jong Kim and co‐workers report a functional DNA‐decorated dynamic Au nanomachine for triple combinatorial anticancer therapy. Two functional DNA moieties, a cytosine rich i‐motif and a guanine rich G‐quadruplex, facilitate loading of a chemotherapeutic drug and a photosensitizer on the Au nanomachine, and subsequently exhibit a therapeutic effect. Moreover, the pH‐responsive aggregation of the Au nanomachines induces a photothermal effect.