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Ångstrom‐Scale Silver Particles as a Promising Agent for Low‐Toxicity Broad‐Spectrum Potent Anticancer Therapy
Author(s) -
Wang ZhenXing,
Chen ChunYuan,
Wang Yang,
Li FuXingZi,
Huang Jie,
Luo ZhongWei,
Rao ShanShan,
Tan YiJuan,
Liu YiWei,
Yin Hao,
Wang YiYi,
He ZeHui,
Xia Kun,
Wu Ben,
Hu XiongKe,
Luo MingJie,
Liu HaoMing,
Chen TuanHui,
Hong ChunGu,
Cao Jia,
Liu ZhengZhao,
Long Ze,
Gan PingPing,
Situ WeiYi,
Fan Rong,
Yuan LingQing,
Xie Hui
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201808556
Subject(s) - in vivo , materials science , broad spectrum , pancreatic cancer , pharmacology , toxicity , apoptosis , cancer , limiting , cancer cell , silver nanoparticle , cancer research , nanotechnology , medicine , nanoparticle , combinatorial chemistry , biology , chemistry , biochemistry , microbiology and biotechnology , mechanical engineering , engineering
Cancer incidence is rising, and the efficacy of current available anticancer agents is limited by severe dose‐limiting toxicities and drug resistance problems. Nanoparticles are heralded as the next frontier in cancer treatment. Here, a pure physical method is used to efficiently fabricate very small silver particles even approaching the Ångstrom (Ång) dimension. Fructose is used as a dispersant and stabilizer to coat the Ång‐scale silver particles (AgÅPs). Functional and mechanistic studies demonstrate that fructose‐coated AgÅPs (F‐AgÅPs) can enter and accumulate in multiple cultured cancer cell lines to induce apoptotic death, whereas most normal cells are resistant to the efficacious dose of F‐AgÅPs; in vivo, intravenous administration of F‐AgÅPs potently inhibits the growth of pancreatic and lung cancer xenografts in nude mice, without inducing notable toxic effects on the healthy tissues. The results suggest the promising potential of F‐AgÅPs as a potent, safe, and broad‐spectrum agent for the cancer treatment.