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Advanced Collagen‐Based Biomaterials for Regenerative Biomedicine
Author(s) -
Lin Kaili,
Zhang Dawei,
Macedo Maria Helena,
Cui Wenguo,
Sarmento Bruno,
Shen Guofang
Publication year - 2019
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201804943
Subject(s) - regeneration (biology) , regenerative medicine , extracellular matrix , self healing hydrogels , materials science , tissue engineering , biomaterial , nanotechnology , biomedicine , biomimetic materials , biomedical engineering , chemistry , engineering , stem cell , bioinformatics , microbiology and biotechnology , biology , biochemistry , polymer chemistry
In recent decades, collagen is one of the most versatile biomaterials used in biomedical applications, mostly due to its biomimetic and structural composition in the extracellular matrix (ECM). Several attempts are proposed for designing innovative collagen‐based biomaterials and applying them in tissue regeneration. The regeneration of different tissues is prompted by different types and diverse physical forms of collagen‐based biomaterials prepared by various methods. Based on such concepts, the source, structure, and classification of collagen are briefly introduced in this review. Here, the commonly used physical forms and modification methods of collagen‐based biomaterials are reviewed, including hydrogels, scaffolds, and microspheres, followed by their applications in the regeneration of tissues and organs. Important proof‐of‐concept examples are described to demonstrate the outcomes on material characteristics, cellular reactions, and tissue regeneration. A concise assessment of the limitations that still exist and the developing trends in the future of collagen‐based biomaterials are put forward.