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A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria
Author(s) -
Li Ying,
Zhao Zheng,
Zhang Jiangjiang,
Kwok Ryan T. K.,
Xie Sheng,
Tang Rongbing,
Jia Yuexiao,
Yang Junchuan,
Wang Le,
Lam Jacky W. Y.,
Zheng Wenfu,
Jiang Xingyu,
Tang Ben Zhong
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201804632
Subject(s) - bacteria , staphylococcus epidermidis , microbiology and biotechnology , escherichia coli , antibacterial activity , multiple drug resistance , biology , gram positive bacteria , bifunctional , antibiotics , staphylococcus aureus , biochemistry , gene , genetics , catalysis
Multidrug‐resistant (MDR) bacteria pose serious threats to public health as there is currently a lack of effective and biocompatible drugs to kill MDR bacteria. Here, a bifunctional aggregation‐induced emission luminogen (AIEgen), triphenylethylene‐naphthalimide triazole (TriPE‐NT), is reported, which is capable of both staining and killing Gram‐positive (G+) and Gram‐negative (G−) bacteria. The intrinsic fluorescence generating ability of the TriPE unit enables TriPE‐NT to monitor the drug–bacteria interactions, meanwhile, the NT unit renders TriPE‐NT the antibacterial activity. Furthermore, TriPE‐NT can generate reactive oxygen species (ROS) under light irradiation and drastically enhance its antibacterial efficacy by photodynamic therapy against wild bacteria and clinical isolated MDR bacteria with a very low toxicity to mammalian cells. Moreover, the efficiency of TriPE‐NT staining on bacteria closely correlates with its antibacterial efficacy. As an example of application, TriPE‐NT is utilized in curing Escherichia coli‐ ( E. coli ), MDR E. coli‐ , Staphylococcus epidermidis‐ ( S. epidermidis ), and MDR S. epidermidis‐ infected wounds on rats with high efficacy and high safety. Thus, TriPE‐NT can be used not only as a powerful antibiotic agent for treating MDR bacteria‐infected diseases but also as a potential fluorescent agent for monitoring the bacterial infections and further exploring the related antibacterial mechanism.