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Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics
Author(s) -
del Rosal Blanca,
Jia Baohua,
Jaque Daniel
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201803733
Subject(s) - nanotechnology , materials science , photothermal therapy , modalities , fluorescence lifetime imaging microscopy , cancer therapy , fluorescence , cancer , medicine , optics , social science , physics , sociology
Nanoparticles (NPs) have attracted great attention for cancer diagnosis and therapy thanks to their unique properties that enable specific tumor uptake, image‐guided diagnosis, and tumor suppression triggered by one or more therapeutic modalities. Light‐activated NPs have gained particular interest as minimally invasive theranostic agents for fluorescence‐guided tumor diagnosis and highly selective phototherapy. The most recent advances in the field focus on shifting their spectral operation range to the second biological window (1000–1400 nm), while improving their efficacy, selectivity, and multifunctionality. In the past few years, multiple systems capable of light‐triggered tumor diagnosis through fluorescence imaging (and in many cases, other imaging modalities) and subsequent tumor therapy have been synthesized and evaluated in small animal models. This review summarizes the different approaches for in vivo tumor theranostics, highlighting their advantages and limitations, and provides a critical analysis of the current state of the field.