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Voltage‐Gated Closed‐Loop Control of Small‐Molecule Release from Alumina‐Coated Nanoporous Gold Thin Film Electrodes
Author(s) -
Li Zidong,
Polat Ozge,
Seker Erkin
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201801292
Subject(s) - nanoporous , materials science , fluorescein , electrode , iontophoresis , thin film , microfluidics , nanotechnology , controlled release , voltage , small molecule , waveform , fluorescence , biomedical engineering , optoelectronics , optics , chemistry , medicine , biochemistry , physics , quantum mechanics , neuroscience , biology
Precise timing and dosing of potent small‐molecule drugs carries significant potential for effective pharmaceutical management of disorders that exhibit time‐varying therapeutic windows such as epilepsy. This study demonstrates the use of alumina‐coated nanoporous gold (np‐Au) thin film electrodes for iontophoretic release of fluorescein as a small‐molecule drug surrogate with picogram dosing and a few seconds temporal resolution. A custom microfluidic platform is engineered to trigger molecular release from an integrated np‐Au chip and monitor the resulting time‐varying fluorescein concentration. Following a systematic study of the influence of applied voltage on loading capacity and release kinetics, a LabVIEW‐based closed‐loop control interface is employed to demonstrate voltage‐gated fluorescein release with preprogrammed arbitrary concentrations waveforms.