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Spiky Fe 3 O 4 @Au Supraparticles for Multimodal In Vivo Imaging
Author(s) -
Wang Weiwei,
Hao Changlong,
Sun Maozhong,
Xu Liguang,
Xu Chuanlai,
Kuang Hua
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201800310
Subject(s) - photothermal therapy , biocompatibility , materials science , photoacoustic imaging in biomedicine , nanotechnology , nanomaterials , in vivo , biomedical engineering , magnetic resonance imaging , optics , radiology , medicine , physics , microbiology and biotechnology , metallurgy , biology
Nanomaterials with high biocompatibility and efficient photothermal conversion have drawn tremendous attention for tumor diagnosis and treatment. In this study, spiky Fe 3 O 4 @Au supraparticles (SPs) are used as phototherapy and multimodal imaging agents. The SPs show excellent photothermal and photodynamic therapeutic effects, with a photothermal conversion efficiency of 31%, and allow tumor‐targeted imaging, including computed tomographic, photoacoustic, and magnetic resonance imaging. The SPs show excellent biocompatibility both in vitro and in vivo. Furthermore, because of their remarkable absorption at near‐infrared region, the SPs obliterate a tumor under 808 nm irradiation. With their capacity for highly integrated multimodal imaging and multiple therapeutic functions, SPs are a promising agent for application to clinical practice.