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Theranostics: Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer (Adv. Funct. Mater. 46/2017)
Author(s) -
Zhou Fangyuan,
Feng Bing,
Wang Tingting,
Wang Dangge,
Cui Zhirui,
Wang Siling,
Ding Chunyong,
Zhang Zhiwen,
Liu Jian,
Yu Haijun,
Li Yaping
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201770272
Subject(s) - prodrug , doxorubicin , photodynamic therapy , reactive oxygen species , drug , cancer research , cancer , breast cancer , materials science , pharmacology , drug delivery , medicine , chemotherapy , oncology , nanotechnology , chemistry , biochemistry , organic chemistry
In article 1703674 , Siling Wang, Haijun Yu, Yaping Li, and co‐workers report a caged doxorubicin prodrug vesicle (RADV) for imaging‐guided cancer therapy. Near‐infrared light illumination generates reactive oxygen species that trigger prodrug activation and ultrafast drug release exactly at the tumor site, thus improving therapeutic efficacy while avoiding the side effects of chemotherapeutics. RADV might provide a novel theranostic nanoplatform for local‐regional management of cancer.