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Drug Delivery: Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug‐Resistant Cancer Cells (Adv. Funct. Mater. 31/2017)
Author(s) -
Zhang Ruili,
Gao Shi,
Wang Zhongliang,
Han Da,
Liu Lin,
Ma Qingjie,
Tan Weihong,
Tian Jie,
Chen Xiaoyuan
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201770179
Subject(s) - micelle , multiple drug resistance , materials science , drug delivery , intracellular , chemotherapeutic drugs , drug , cancer therapy , nanotechnology , cancer cell , cancer , pharmacology , cancer research , biophysics , drug resistance , chemistry , biology , medicine , biochemistry , organic chemistry , aqueous solution , microbiology and biotechnology
An anti‐MDR1 molecular‐beacon‐based micelle nanosystem is demonstrated by Zhongliang Wang, Qingjie Ma, Xiaoyuan Chen, and co‐workers in article number 1701027 . Owing to its ingenious design, the nanosystem is able to successfully administer both a MDR1 gene silencer and a chemotherapeutic agent in a sequential way to produce a synergistic therapeutic effect, enhancing chemotherapeutic efficacy to OVCAR8/ADR cells significantly.