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Immunotherapy: Engineering Immunological Tolerance Using Quantum Dots to Tune the Density of Self‐Antigen Display (Adv. Funct. Mater. 22/2017)
Author(s) -
Hess Krystina L.,
Oh Eunkeu,
Tostanoski Lisa H.,
Andorko James I.,
Susumu Kimihiro,
Deschamps Jeffrey R.,
Medintz Igor L.,
Jewell Christopher M.
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201770132
Subject(s) - reprogramming , immunotherapy , materials science , antigen , quantum dot , cancer immunotherapy , immunology , microbiology and biotechnology , nanotechnology , biology , cell , immune system , genetics
In article number 1700290 , Christopher M. Jewell and co‐workers use quantum dots (yellow) to track and control the display density of self‐molecules mistakenly attacked during autoimmune diseases. This precise display changes self‐molecule processing by antigen‐presenting cells (purple), reprogramming the disease‐driving inflammatory T cells (red) to become regulatory T cells (developing white region on cell) that control disease and eliminate paralysis.