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4D Biofabrication: 3D Cell Patterning Using Shape‐Changing Films
Author(s) -
Stroganov Vladislav,
Pant Jitendra,
Stoychev Georgi,
Janke Andreas,
Jehnichen Dieter,
Fery Andreas,
Handa Hitesh,
Ionov Leonid
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201706248
Subject(s) - biofabrication , materials science , fabrication , nanotechnology , polymer , tissue engineering , composite material , biomedical engineering , medicine , alternative medicine , pathology
A novel approach for fabrication of 3D cellular structures using new thermosensitive shape‐changing polymer films with photolithographically patterned surface—4D biofabrication is reported. The surface of shape‐changing polymer films is patterned to selectively adsorb cells in specific regions. The 2D cell pattern is converted to the 3D cell structure after temperature‐induced folding of the polymer films. This approach has a great potential in the field of tissue engineering and bioscaffolds fabrication.