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An Integrated Multifunctional Nanoplatform for Deep‐Tissue Dual‐Mode Imaging
Author(s) -
Yang Fan,
Skripka Artiom,
Benayas Antonio,
Dong Xianke,
Hong Sung Hwa,
Ren Fuqiang,
Oh Jung Kwon,
Liu Xinyu,
Vetrone Fiorenzo,
Ma Dongling
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201706235
Subject(s) - materials science , photoluminescence , autofluorescence , superparamagnetism , near infrared spectroscopy , optoelectronics , magnetic resonance imaging , nanotechnology , biocompatible material , fluorescence , biomedical engineering , optics , magnetic field , magnetization , medicine , physics , quantum mechanics , radiology
The combination of biocompatible superparamagnetic and photoluminescent nanoparticles (NPs) is intensively studied as highly promising multifunctional (magnetic confinement and targeting, imaging, etc.) tools in biomedical applications. However, most of these hybrid NPs exhibit low signal contrast and shallow tissue penetration for optical imaging due to tissue‐induced optical extinction and autofluorescence, since in many cases, their photoluminescent components emit in the visible spectral range. Yet, the search for multifunctional NPs suitable for high photoluminescence signal‐to‐noise ratio, deep‐tissue imaging is still ongoing. Herein, a biocompatible core/shell/shell sandwich structured Fe 3 O 4 @SiO 2 @NaYF 4 :Nd 3+ nanoplatform possessing excellent superparamagnetic and near‐infrared (excitation) to near‐infrared (emission), i.e., NIR‐to‐NIR photoluminescence properties is developed. They can be rapidly magnetically confined, allowing the NIR photoluminescence signal to be detected through a tissue as thick as 13 mm, accompanied by high T 2 relaxivity in magnetic resonance imaging. The fact that both the excitation and emission wavelengths of these NPs are in the optically transparent biological windows, along with excellent photostability, fast magnetic response, significant T 2 ‐contrast enhancement, and negligible cytotoxicity, makes them extremely promising for use in high‐resolution, deep‐tissue dual‐mode (optical and magnetic resonance) in vivo imaging and magnetic‐driven applications.