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Nanomotor‐Based Strategy for Enhanced Penetration across Vasculature Model
Author(s) -
Peng Fei,
Men Yongjun,
Tu Yingfeng,
Chen Yongming,
Wilson Daniela A.
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201706117
Subject(s) - polymersome , materials science , polystyrene , penetration (warfare) , ethylene glycol , acrylic acid , copolymer , nanotechnology , chemical engineering , polymer , composite material , amphiphile , operations research , engineering
Here the first nanomotor‐based strategy is reported to effectively cross tumor vasculature endothelium. The designed nanomotors are based on (poly(ethylene glycol)‐ b ‐polystyrene and poly(acrylic acid)‐ b ‐polystyrene) building blocks, which further self‐assemble into polymersomes of tunable sizes (100, 300 nm). The polymersomes are readily loaded with hydrophilic model drug into the aqueous compartment. A catalytic platinum cap is then partially deposited on the surface of the polymersome via electron beam evaporation, resulting in a polymersome Janus nanomotor. In a tumor vasculature model, these cargo‐loaded polymersome nanomotors demonstrate enhanced penetration across the endothelium.