Premium
High‐Strength, Durable All‐Silk Fibroin Hydrogels with Versatile Processability toward Multifunctional Applications
Author(s) -
Zhu Zhenghua,
Ling Shengjie,
Yeo Jingjie,
Zhao Siwei,
Tozzi Lorenzo,
Buehler Markus J.,
Omenetto Fiorenzo,
Li Chunmei,
Kaplan David L.
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201704757
Subject(s) - self healing hydrogels , materials science , fibroin , silk , polymer , solvent , nanotechnology , elastic modulus , modulus , composite material , chemical engineering , polymer chemistry , organic chemistry , chemistry , engineering
Hydrogels are the focus of extensive research due to their potential use in fields including biomedical, pharmaceutical, biosensors, and cosmetics. However, the general weak mechanical properties of hydrogels limit their utility. Here, pristine silk fibroin (SF) hydrogels with excellent mechanical properties are generated via a binary‐solvent‐induced conformation transition (BSICT) strategy. In this method, the conformational transition of SF is regulated by moderate binary solvent diffusion and SF/solvent interactions. β‐sheet formation serves as the physical crosslinks that connect disparate protein chains to form continuous 3D hydrogel networks, avoiding complex chemical and/or physical treatments. The Young's modulus of these new BSICT–SF hydrogels can reach up to 6.5 ± 0.2 MPa, tens to hundreds of times higher than that of conventional hydrogels (0.01–0.1 MPa). These new materials fill the “empty soft materials' space” in the elastic modulus/strain Ashby plot. More remarkably, the BSICT–SF hydrogels can be processed into different constructions through different polymer and/or metal‐based processing techniques, such as molding, laser cutting, and machining. Thus, these new hydrogel systems exhibit potential utility in many biomedical and engineering fields.