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Highly Condensed Boron Cage Cluster Anions in 2D Carrier and Its Enhanced Antitumor Efficiency for Boron Neutron Capture Therapy
Author(s) -
Choi Goeun,
Jeon IeRang,
Piao Huiyan,
Choy JinHo
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201704470
Subject(s) - boron , biodistribution , neutron capture , radiochemistry , materials science , isotopes of boron , drug delivery , hydroxide , irradiation , nuclear chemistry , nanotechnology , chemistry , in vitro , organic chemistry , biochemistry , physics , nuclear physics
An attempt is made to apply layered double hydroxide (LDH) as a boron delivery carrier for boron neutron capture therapy (BNCT), which needs a sufficient amount of boron in tumor cells for its successful administration. To meet this requirement, a nanohybrid (BSH‐LDH), mercaptoundecahydro‐closo‐dodecaborate (BSH) anionic molecules in LDH, is developed as a boron delivery system. The cellular boron content upon permeation of BSH‐LDH nanoparticles (42.4 µg 10 B 10 −6 cells) in U87 glioblastoma cell line is found to be ≈2000 times larger than the minimum boron requirement (≈0.02 µg 10 B 10 −6 cells) for BNCT and also orders of magnitude higher than the previous results (0.2–1.5 µg 10 B 10 −6 cells) by those applied with other targeting strategies, and eventually results in excellent neutron capture efficiency even under such low dose (30 µg 10 B mL −1 ) and weak irradiation (1 × 10 12 n cm −2 corresponding to 20 min) condition. According to the biodistribution studies in xenograft mice model, the tumor‐to‐blood ratio of BSH in the BSH‐LDH‐treated‐group is found to be 4.4‐fold higher than that in the intact BSH treated one in 2 h after drug treatment. The present BNCT combined with boron delivery system provides a promising integrative therapeutic platform for cancer treatment.