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Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects
Author(s) -
Diba Mani,
Camargo Winston A.,
Brindisi Mariateresa,
Farbod Kambiz,
Klymov Alexey,
Schmidt Stephan,
Harrington Matthew J.,
Draghi Lorenza,
Boccaccini Aldo R.,
Jansen John A.,
van den Beucken Jeroen J. J. P.,
Leeuwenburgh Sander C. G.
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201703438
Subject(s) - gelatin , materials science , bioactive glass , composite number , regeneration (biology) , colloid , biomedical engineering , bone tissue , surface modification , nanoparticle , adhesion , nanocomposite , bisphosphonate , composite material , nanotechnology , chemical engineering , osteoporosis , medicine , chemistry , pathology , organic chemistry , engineering , biology , microbiology and biotechnology
Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self‐healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri‐implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.