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Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy
Author(s) -
Zhang Fan,
Zhao Longjian,
Wang Shumin,
Yang Jun,
Lu Guihong,
Luo Nana,
Gao Xiaoyong,
Ma Guanghui,
Xie HaiYan,
Wei Wei
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201703326
Subject(s) - magnetosome , materials science , magnetotactic bacteria , nanotechnology , cytoplasm , cancer therapy , drug delivery , microbiology and biotechnology , biophysics , cancer , biology , magnetite , genetics , metallurgy
Precisely delivering siRNA to its target site in cancer cells is a high‐demanding but challenging task. Herein, a biomimetic magnetosome is developed using magnetic nanocluster (MNC) as the core and Arg–Gly–Asp (RGD) decorated macrophage membrane as the cloak, which is achieved via a combination of MNC synthesis, azide‐membrane engineering, electrical assembly, and click chemistry. Such a feature‐packed magnetosome enables us to gain the success of high‐performance siRNA delivery through superior stealth effect, magnetic resonance imaging, magnetic accumulation, RGD targeting, and favorable cytoplasm trafficking. As a result, target gene expression can be significantly suppressed and tumor growth is effectively inhibited, while the systemic toxicity is not notable. These results together vote the biomimetic magnetosome as a promising siRNA delivery system for anticancer therapy.