Premium
Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring
Author(s) -
Ganji Mehran,
Kaestner Erik,
Hermiz John,
Rogers Nick,
Tanaka Atsunori,
Cleary Daniel,
Lee Sang Heon,
Snider Jospeh,
Halgren Mila,
Cosgrove Garth Rees,
Carter Bob S.,
Barba David,
Uguz Ilke,
Malliaras George G.,
Cash Sydney S.,
Gilja Vikash,
Halgren Eric,
Dayeh Shadi A.
Publication year - 2018
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201700232
Subject(s) - pedot:pss , microelectrode , materials science , neurophysiology , electrode , nanotechnology , biomedical engineering , neural activity , neuroscience , medicine , chemistry , layer (electronics) , biology
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal‐to‐noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus‐locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 µm, potentially enabling basic neurophysiology studies at the scale of neural micro‐circuitry.