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siRNA Delivery: A Fluorinated Bola‐Amphiphilic Dendrimer for On‐Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species (Adv. Funct. Mater. 47/2016)
Author(s) -
Liu Xiaoxuan,
Wang Yang,
Chen Chao,
Tintaru Aura,
Cao Yu,
Liu Juan,
Ziarelli Fabio,
Tang Jingjie,
Guo Hongbo,
Rosas Roseline,
Giorgio Suzanne,
Charles Laurence,
Rocchi Palma,
Peng Ling
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670307
Subject(s) - dendrimer , amphiphile , materials science , reactive oxygen species , nanotechnology , small interfering rna , biophysics , drug delivery , rna , polymer chemistry , chemistry , biochemistry , copolymer , polymer , biology , composite material , gene
A fluorinated bola‐amphiphilic dendrimer, sensitive to the reactive oxygen species, and its application in specific delivery of small interfering RNA in cancer cells, is reported by L. Peng and co‐workers on page 8594. The dendrimer combines both lipid and dendrimer delivery advantages along with fluorine tags enabling 19 F NMR studies on the delivery process, constituting a promising vector for on‐demand stimulus‐responsive delivery.