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Tissue Repair: Development of Therapeutic Small‐Molecule Fluorophore for Cell Transplantation (Adv. Funct. Mater. 46/2016)
Author(s) -
Wang Xin,
Chen Zelin,
Luo Shenglin,
Jin Taotao,
Wang Yu,
Chen Fuqin,
Wu Liao,
Tan Xu,
Shi Chunmeng
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670301
Subject(s) - fluorophore , transplantation , cytoprotection , materials science , cell survival , cell , regeneration (biology) , fluorescence , nanotechnology , biophysics , microbiology and biotechnology , cancer research , oxidative stress , medicine , apoptosis , chemistry , biology , biochemistry , surgery , physics , quantum mechanics
The clinical application of cell‐based therapy is severely hampered by restricted cell survival and poor understanding of cell fate after transplantation. C. Shi and co‐workers describe a novel near‐infrared mitochondria‐targeting heptamethine dye (NIRCP‐61) on page 8397, developed to simultaneously enable cell tracking and cytoprotection in cytotherapy. This small‐molecule fluorophore maintains superior fluorescent imaging properties while inducing cytoprotective effects against oxidative stress to augment tissue repair and regeneration.