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Hyperammonemia: Liposome‐Supported Peritoneal Dialysis for the Treatment of Hyperammonemia‐Associated Encephalopathy (Adv. Funct. Mater. 46/2016)
Author(s) -
Agostoni Valentina,
Lee Soo Hyeon,
Forster Vincent,
Kabbaj Meriam,
Bosoi Cristina R.,
Tremblay Mélanie,
Zadory Matthias,
Rose Christopher F.,
Leroux JeanChristophe
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670300
Subject(s) - hyperammonemia , peritoneal dialysis , encephalopathy , liposome , materials science , pharmacology , medicine , nanotechnology
On page 8382, J.‐C. Leroux and co‐workers describe a novel approach for treating hyperammonemia induced encephalopathy, based on the peritoneal infusion of giant transmembrane pH‐gradient liposomes bearing an acidic core. These scavenging vesicles allow a safe and effective removal of excess ammonia, outperforming conventional peritoneal dialysis fluids and significantly attenuating brain edema in a rodent model of liver disease.