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Nanovesicles: Bioengineered Extracellular Membranous Nanovesicles for Efficient Small‐Interfering RNA Delivery: Versatile Platforms for Stem Cell Engineering and In Vivo Delivery (Adv. Funct. Mater. 32/2016)
Author(s) -
Jin Yoonhee,
Lee Jung Seung,
Min Sungjin,
Park HyunJi,
Kang Taek Jin,
Cho SeungWoo
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670210
Subject(s) - small interfering rna , in vivo , microbiology and biotechnology , stem cell , tissue engineering , materials science , cell , drug delivery , mesenchymal stem cell , biophysics , extracellular , nanotechnology , rna , biomedical engineering , biology , biochemistry , medicine , gene
On page 5804, S.‐W. Cho and co‐workers propose cell‐derived bioengineered extracellular membranous nanovesicles as a novel small‐interfering RNA (siRNA) delivery system, and explore their potencies for stem cell engineering and in vivo delivery. Modification of these nanovesicles via overexpression of various target peptides or proteins on plasma membrane significantly improves siRNA delivery for enhanced differentiation in several types of human stem cells and potential therapeutic applications in vivo.