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Decellularized Cartilage Microparticles: Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation (Adv. Funct. Mater. 30/2016)
Author(s) -
Novak Tyler,
Seelbinder Benjamin,
Twitchell Celina M.,
VoytikHarbin Sherry L.,
Neu Corey P.
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670195
Subject(s) - cartilage , decellularization , materials science , articular cartilage , biomedical engineering , tissue engineering , nanotechnology , anatomy , pathology , medicine , osteoarthritis , alternative medicine
On page 5427, C. P. Neu and co‐workers report on successfully combining the benefits of native tissue biochemistry/structure with the tunability of reconstituted biomaterials for the formation of clinically relevant tissue composites. Native articular cartilage and reconstituted type I collagen form a moldable ‘cartilage clay’ that can be custom designed to meet the mechanical, biochemical, and geometric needs of a clinical implant; showing the capability to locally differentiate progenitor cells.