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Drug Delivery: The Application of Stimuli‐Responsive VEGF‐ and ATP‐Aptamer‐Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells (Adv. Funct. Mater. 24/2016)
Author(s) -
Liao WeiChing,
Sohn Yang Sung,
Riutin Marianna,
Cecconello Alessandro,
Parak Wolfgang J.,
Nechushtai Rachel,
Willner Itamar
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670153
Subject(s) - cytotoxicity , aptamer , cancer cell , doxorubicin , drug , adenosine triphosphate , drug delivery , cancer drugs , materials science , targeted drug delivery , pharmacology , cancer , cancer research , nanotechnology , biochemistry , chemistry , medicine , biology , microbiology and biotechnology , chemotherapy , in vitro
Adenosine triphosphate (ATP)–responsive DNA‐based microcapsules loaded with the chemotherapeutic doxorubicin drug are synthesized and incorporated into cancer cells. I. Willner and co‐workers find, on page 4262, that over‐expressed ATP in cancer cells dissociates the microcapsules and releases the drug, resulting in selective cytotoxicity toward cancer cells.