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Drug Delivery: Thiolation and Cell‐Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin (Adv. Funct. Mater. 20/2016)
Author(s) -
Shrestha Neha,
Araújo Francisca,
Shahbazi MohammadAli,
Mäkilä Ermei,
Gomes Maria João,
HerranzBlanco Bárbara,
Lindgren Rici,
Granroth Sari,
Kukk Edwin,
Salonen Jarno,
Hirvonen Jouni,
Sarmento Bruno,
Santos Hélder A.
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670124
Subject(s) - materials science , surface modification , drug delivery , porous silicon , nanotechnology , nanoparticle , peptide , porosity , chemical engineering , composite material , biochemistry , chemistry , engineering
Mucoadhesive and cell‐associating porous silicon‐based nanoparticles for oral delivery of insulin are described by N. Shrestha, H. A. Santos, and co‐workers on page 3405. Using a highly efficient top‐down approach and simple crosslinking chemistry, porous silicon nanoparticles (NPs) are modified with l ‐cysteine‐ and cell‐penetrating‐peptides to enhance permeation of insulin across the intestine wall, through the close proximity to the intestinal epithelia.