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Targeted Oral Drug Delivery: Chitosan–Alginate Microcapsules Provide Gastric Protection and Intestinal Release of ICAM‐1‐Targeting Nanocarriers, Enabling GI Targeting In Vivo (Adv. Funct. Mater. 20/2016)
Author(s) -
Ghaffarian Rasa,
PérezHerrero Edgar,
Oh Hyuntaek,
Raghavan Srinivasa R.,
Muro Silvia
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670123
Subject(s) - nanocarriers , chitosan , drug delivery , in vivo , pharmacology , materials science , drug , targeted drug delivery , nanotechnology , medicine , chemistry , biochemistry , biology , microbiology and biotechnology
On page 3382, S. Muro and co‐workers explore the protective effects of a chitosan shell against gastric degradation of orally administered drug nanocarriers. Antibodies targeted to the intestine are loaded into alginate nanocarriers and encapsulated with chitosan. The encapsulation improves delivery to the target, by protecting against the effects of gastric conditions, promoting higher targeting to the intestinal region.