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Microstructures: Mechanisms and Microenvironment Investigation of Cellularized High Density Gradient Collagen Matrices via Densification (Adv. Funct. Mater. 16/2016)
Author(s) -
Novak Tyler,
Seelbinder Benjamin,
Twitchell Celina M.,
van Donkelaar Corrinus C.,
VoytikHarbin Sherry L.,
Neu Corey P.
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670103
Subject(s) - materials science , fibril , microstructure , collagen fibril , articular cartilage , cartilage , biophysics , composite material , anatomy , medicine , alternative medicine , pathology , biology , osteoarthritis
Biomaterials often have characteristic spatial gradients in physical properties that lead to specialized function. On page 2617, C. P. Neu and co‐workers form gradient matrices of natural biopolymers using a densification process that exudes fluid from the structure, leading to a reproducible reorganization of collagen and embedded cells. High‐density regions show increased fibril packing, mechanical properties, and fibril thickness, on par with values observed in native tissues like articular cartilage.