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Vaccines: Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant (Adv. Funct. Mater. 15/2016)
Author(s) -
Kim Ki Su,
Kim Hyemin,
Park Yunji,
Kong Won Ho,
Lee Seung Woo,
Kwok Sheldon J. J.,
Hahn Sei Kwang,
Yun Seok Hyun
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670094
Subject(s) - adjuvant , nanocarriers , transdermal , immune system , vaccination , materials science , medicine , dendritic cell , immunology , cancer research , pharmacology , nanotechnology , drug delivery
On page 2512, S. K. Hahn, S. H. Yun, and co‐workers report needle‐free topical vaccination using a vaccine carrier of hyaluronan (HA) and laser adjuvant. HA–vaccine conjugates are shown to diffuse through the intact skin barrier and activate dendritic cells, which then migrate to lymph nodes to elicit immune responses. The non‐ablative laser adjuvant primes the dendritic cells to achieve a high dose response comparable to that of conventional intramuscular injection.