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Nanostructures: Highly Scalable, Closed‐Loop Synthesis of Drug‐Loaded, Layer‐by‐Layer Nanoparticles (Adv. Funct. Mater. 7/2016)
Author(s) -
Correa Santiago,
Choi Ki Young,
Dreaden Erik C.,
Renggli Kasper,
Shi Aria,
Gu Li,
Shopsowitz Kevin E.,
Quadir Mohiuddin A.,
BenAkiva Elana,
Hammond Paula T.
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670044
Subject(s) - materials science , nanoparticle , polymer , polystyrene , layer by layer , polyelectrolyte , nanotechnology , layer (electronics) , chemical engineering , drug delivery , composite material , engineering
P. T. Hammond and co‐workers present a technique that uses tangential flow filtration for rapid, high‐yield preparation of biomedically relevant layer‐by‐layer nanoparticles. Diverse nanoparticles with diameters ranging from 40 to 150 nm were prepared from polystyrene, mesoporous silica, and drug‐loaded liposomal cores. Using this technique, nanoparticles could be coated with a broad range of polyelectrolytes including polysaccharides, polypeptides, and synthetic polymers. The prepared nanoparticles are suitable for long‐term storage under refrigerated conditions, as well as for lyophilized, room‐temperature storage.