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Nanostructures: Enhanced Differentiation of Human Embryonic Stem Cells Toward Definitive Endoderm on Ultrahigh Aspect Ratio Nanopillars (Adv. Funct. Mater. 6/2016)
Author(s) -
Rasmussen Camilla Holzmann,
Reynolds Paul M.,
Petersen Dorthe Roenn,
Hansson Mattias,
McMeeking Robert M.,
Dufva Martin,
Gadegaard Nikolaj
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201670038
Subject(s) - nanopillar , materials science , nanotechnology , substrate (aquarium) , endoderm , embryonic stem cell , stem cell , nanostructure , microbiology and biotechnology , biology , biochemistry , gene , ecology
N. Gadegaard and co‐workers report on page 815 a nanofabricated thermoplastic substrate with ultra‐high aspect ratio nanopillars. This substrate, formed via injection molding, is used to enhance the differentiation of human embryonic stem cells. The nanostructured surface results in a softer substrate, which mimics the natural extracellular environment.