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Ultrasmall CuCo 2 S 4 Nanocrystals: All‐in‐One Theragnosis Nanoplatform with Magnetic Resonance/Near‐Infrared Imaging for Efficiently Photothermal Therapy of Tumors
Author(s) -
Li Bo,
Yuan Fukang,
He Guanjie,
Han Xiaoyu,
Wang Xin,
Qin Jinbao,
Guo Zheng Xiao,
Lu Xinwu,
Wang Qian,
Parkin Ivan P.,
Wu Chengtie
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201606218
Subject(s) - photothermal therapy , materials science , bimetal , ternary operation , nanocrystal , photothermal effect , optoelectronics , infrared , magnetic resonance imaging , nanotechnology , optics , physics , computer science , composite material , programming language , medicine , radiology
Copper‐based ternary bimetal chalcogenides have very promising potential as multifunctional theragnosis nanoplatform for photothermal treatment of tumors. However, the design and synthesis of such an effective platform remains challenging. In this study, hydrophilic CuCo 2 S 4 nanocrystals (NCs) with a desirable size of ≈10 nm are synthesized by a simple one‐pot hydrothermal route. The as‐prepared ultrasmall CuCo 2 S 4 NCs show: 1) intense near‐infrared absorption, which is attributed to 3d electronic transitions from the valence band to an intermediate band, as identified by density functional theory calculations; 2) high photothermal performance with a photothermal conversion efficiency up to 73.4%; and 3) capability for magnetic resonance (MR) imaging, as a result of the unpaired 3d electrons of cobalt. Finally, it is demonstrated that the CuCo 2 S 4 NCs are a promising “all‐in‐one” photothermal theragnosis nanoplatform for photothermal cancer therapy under the irradiation of a 915 nm laser at a safe power density of 0.5 W cm −2 , guided by MR and infrared thermal imaging. This work further promotes the potential applications of ternary bimetal chalcogenides for photothermal theragnosis therapy.