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Fabricating Aptamer‐Conjugated PEGylated‐MoS 2 /Cu 1.8 S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo‐Photothermal Therapy of Cancer
Author(s) -
Meng Xiangdan,
Liu Zhiqiang,
Cao Yu,
Dai Wenhao,
Zhang Kai,
Dong Haifeng,
Feng Xiaoyan,
Zhang Xueji
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201605592
Subject(s) - photothermal therapy , materials science , doxorubicin , nanotechnology , aptamer , nanomedicine , biocompatibility , drug delivery , polyethylene glycol , fluorescence lifetime imaging microscopy , cancer research , biomedical engineering , nanoparticle , chemotherapy , medicine , fluorescence , chemistry , microbiology and biotechnology , biology , surgery , organic chemistry , metallurgy , physics , quantum mechanics
Fabricating theranostic nanoparticles combining multimode disease diagnosis and therapeutic has become an emerging approach for personal nanomedicine. However, the diagnostic capability, biocompatibility, and therapeutic efficiency of theranostic nanoplatforms limit their clinic widespread applications. Targeting to the theme of accurate diagnosis and effective therapy of cancer cells, a multifunctional nanoplatform of aptamer and polyethylene glycol (PEG) conjugated MoS 2 nanosheets decorated with Cu 1.8 S nanoparticles (ATPMC) is developed. The ATPMC nanoplatform accomplishes photoluminescence imaging, photoacoustic imaging, and photothermal imaging for in vitro and in vivo tumor cells imaging diagnosis. Meanwhile, the ATPMC nanoplatform facilitates selective delivery of gene probe to detect intracellular microRNA aberrantly expressed in cancer cells and anticancer drug doxorubicin (DOX) for chemotherapy. Moreover, the synergistic interaction of MoS 2 and Cu 1.8 S renders the ATPMC nanoplatform with superb photothermal conversion efficiency. The ATPMC nanoplatform loaded with DOX displays near‐infrared laser‐induced programmed chemotherapy and advanced photothermal therapy, and the targeted chemo‐photothermal therapy presents excellent antitumor efficiency.