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1T‐Phase WS 2 Protein‐Based Biosensor
Author(s) -
Toh Rou Jun,
MayorgaMartinez Carmen C.,
Sofer Zdenek,
Pumera Martin
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201604923
Subject(s) - biosensor , materials science , glutaraldehyde , electrochemistry , phase (matter) , conductivity , selectivity , chemical engineering , electrode , hydrogen peroxide , nanotechnology , analytical chemistry (journal) , catalysis , chemistry , chromatography , organic chemistry , engineering
Metallic 1T‐phase transition metal dichalcogenides have been recognized for their desirable properties like high surface‐to‐volume ratio, high conductivity, and capacitive behavior, making them outstanding for catalytic and sensing applications. Herein, a hydrogen peroxide (H 2 O 2 ) biosensor is constructed by the immobilization of hemoglobin (Hb) on 1T‐phase WS 2 (1T‐WS 2 ) sheets, and entrapment by glutaraldehyde. 1T‐WS 2 not only displays electrocatalytic activity toward the reduction of H 2 O 2 but also provides a high surface‐to‐volume ratio and conductive platform for the immobilization of Hb and facilitation of its electron transfer to the electrode surface. The advantageous role of 1T‐phase WS 2 is further demonstrated for the construction of a heme‐based H 2 O 2 biosensor compared to its 1T‐phase MoS 2, MoSe 2 , and WSe 2 counterparts. Synergistic interactions between 1T‐WS 2 and Hb result in a H 2 O 2 biosensor with high analytical performance in terms of wide range, sensitivity, selectivity, reproducibility, repeatability, and stability. These findings have profound impact in the research fields of electrochemical sensing and biodiagnostics.