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In Situ Multimodality Imaging of Cancerous Cells Based on a Selective Performance of Fe 2+ ‐Adsorbed Zeolitic Imidazolate Framework‐8
Author(s) -
Du Tianyu,
Zhao Chunqiu,
ur Rehman Fawad,
Lai Lanmei,
Li Xiaoqi,
Sun Yi,
Luo Shouhua,
Jiang Hui,
Gu Ning,
Selke Matthias,
Wang Xuemei
Publication year - 2017
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201603926
Subject(s) - zeolitic imidazolate framework , imidazolate , nanoclusters , materials science , adsorption , in vivo , metal organic framework , in situ , paramagnetism , nanotechnology , alkalinity , inorganic chemistry , chemistry , organic chemistry , quantum mechanics , biology , physics , microbiology and biotechnology
Metal‐organic frameworks possess tremendous potential in biomedical areas for their particular structure. In this study, the authors explored Fe 2+ ‐adsorbed nanoscaled zeolitic imidazolate framework‐8 (ZIF‐8) for in vivo multimodal imaging of cancerous cells for early diagnosis of target cancers. The observations demonstrate that adding Fe 2+ into the suspension of ZIF‐8 can neutralize the alkalinity and lower toxicity, while the Fe 2+ ‐adsorbed ZIF‐8 can readily transform to fluorescence ZnO and super paramagnetic Fe 3 O 4 under the synergistic reaction of ROS, GSH, and acids. It is evident that the formation of the nanoclusters ZnO and Fe 3 O 4 only occurred in cancerous cells and does not take place in normal cells, which can be attributed to the different ROS levels and specific micro‐environment in tumor and normal cells. This raises the possibility for the Fe 2+ ‐adsorbed zeolitic imidazolate frameworks to act as promising agents for the in vivo multimodal imaging of cancers in their early stage.