Premium
All‐in‐One Theranostic Nanoplatform Based on Hollow TaOx for Chelator‐Free Labeling Imaging, Drug Delivery, and Synergistically Enhanced Radiotherapy
Author(s) -
Song Guosheng,
Chao Yu,
Chen Yuyan,
Liang Chao,
Yi Xuan,
Yang Guangbao,
Yang Kai,
Cheng Liang,
Zhang Qiao,
Liu Zhuang
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201603845
Subject(s) - nanoshell , materials science , polyethylene glycol , radiation therapy , drug delivery , nanotechnology , photothermal therapy , peg ratio , mesoporous silica , nanoparticle , biomedical engineering , mesoporous material , chemistry , medicine , radiology , organic chemistry , finance , economics , catalysis
Despite extensive use of radiotherapy in cancer treatment, there has been huge demand to improve its efficacy and accuracy in tumor destruction. To this end, nanoparticle‐based radiosensitizers, particularly those with high‐Z elements, have been explored to enhance radiotherapy. Meanwhile, imaging is an essential tool prior to the individual planning of precise radiotherapy. Here, hollow tantalum oxide (H‐TaOx) nanoshells are prepared using a one‐pot template‐free method and then modified with polyethylene glycol (PEG), yielding H‐TaOx‐PEG nanoshells for imaging‐guided synergistically enhanced radiotherapy. H‐TaOx‐PEG nanoshells show strong intrinsic binding with metal ions such as Fe 3+ and 99m Tc 4+ upon simple mixing, enabling magnetic resonance imaging and single photon emission computed tomography imaging, respectively, which are able to track in vivo distribution of those nanoshells and locate the tumor. With mesoporous shells and large cavities, those H‐TaOx‐PEG nanoshells show efficient loading of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), a hydrophobic chemotherapeutic drug. By means of the radiosensitization effect of Ta to deposit X‐ray energy inside tumors, as well as SN‐38‐induced cell cycle arrest into radiation‐sensitive phases, H‐TaOx‐PEG@SN‐38 can offer remarkable synergistic therapeutic outcome in the combined chemoradiotherapy. Without appreciable systemic toxicity, such hollow‐TaOx nanostructure may therefore find promising applications in multimodal imaging and enhanced cancer radiotherapy.